通过DREADD介导的杏仁体激活足以在年轻的非人类灵长类动物中引起类似焦虑的反应
Sascha A L Mueller1, Jonathan A Oler1, Patrick H Roseboom1
1Department of Psychiatry and the HealthEmotions Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719, USA.
bioRxiv : the preprint server for biology
|June 19, 2023
概括
独家激活设计者药物 (DREADDs) 的设计者受体在中增加了杏仁体活动,导致了类似焦虑的行为. 这种灵长类模型显示了研究病态焦虑的长期潜力.
科学领域:
- 神经科学是一个神经科学.
- 灵长类动物模型
- 精神疾病 精神疾病
背景情况:
- 焦虑障碍很常见,通常从青春期开始.
- 了解病态焦虑的神经生物学基础至关重要.
结论:
- 灵长类桃体神经元的选择性激活可以诱导与焦虑相关的行为.
- 这种基于DREADD的灵长类模型为研究人类病态焦虑提供了宝贵的工具.
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