评估时间型与怀孕和围产期结局的因果关系及其与失眠和睡眠持续时间的相互作用:一项门德尔随机化研究
medRxiv : the preprint server for health sciences
|June 19, 2023
概括
晚间时刻型没有对怀孕结果产生不良影响. 然而,夜间时代型妇女的失眠可能会增加早产风险,这需要进一步研究.
科学领域:
- 生殖健康 生殖健康
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
背景情况:
- 观察性研究表明,时间型和怀孕结果之间存在联系,但因果关系尚不清楚.
- 了解时型的遗传基础可以帮助阐明它在生殖健康中的作用.
研究的目的:
- 调查遗传预测的晚间时代型与怀孕和周围产生的结果的因果关系.
- 探索与这些结果相关的时间型,失眠和睡眠时间之间的潜在相互作用.
主要方法:
- 采用双样本的门德尔随机化 (MR),使用与时间型相关的遗传变异.
- 分析了来自英国大型生物库,ALSPAC,BiB,MoBa和FinnGen队伍的数据.
- 逆方差加权 (IVW) 分析是主要方法,加权中位数和MR-Egger作为灵敏度分析.
主要成果:
- 没有找到强有力的证据证明时间型对怀孕和围产期结果的因果关系.
- 观察到一种显著的相互作用:失眠与早产风险增加有关,特别是在基因预测晚间时间型 (OR 1.61) 的女性中.
- 对于其他结果,在时间型和失眠之间没有发现显著的相互作用,对于任何结果,在时间型和睡眠时间之间也没有发现显著的相互作用.
结论:
- 这项研究表明,夜间时型本身可能不会对怀孕结果产生不利影响.
- 对于患有失眠症和晚间类型的女性来说,存在潜在的早产风险增加,这凸显了需要进一步调查的必要性.
- 研究结果强调,在生育年龄的女性中,考虑睡眠障碍,特别是失眠的重要性,这些女性在生育年龄期间有晚间时间类型.
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