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一个半导体96微板平台用于基于电成像的高通量表型选.

Shalaka Chitale, Wenxuan Wu, Avik Mukherjee

    bioRxiv : the preprint server for biology
    |June 19, 2023
    PubMed
    概括
    此摘要是机器生成的。

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    一个新的半导体微板平台能够在规模上对活细胞进行高分辨率,实时阻抗成像. 这项技术推进了无标签的功能细胞分析,用于药物发现和作用机制分析.

    科学领域:

    • 生物技术是生物技术.
    • 细胞生物学 细胞生物学
    • 药物发现 药物发现 药物发现

    背景情况:

    • 高含量成像在药物发现中很受欢迎,但仅限于固定细胞.
    • 现有的无标签电子设备缺乏高分辨率或吞吐量.
    • 需要可扩展,高分辨率的活细胞分析平台.

    研究的目的:

    • 开发一个半导体96微板平台,用于高分辨率,实时阻抗成像.
    • 为了能够在规模上对活细胞进行无标签的功能性分析.
    • 扩大高通量作用机制 (MOA) 分析和表型药物发现中的应用.

    主要方法:

    • 设计了一个半导体96微板,每个井有4096个电极 (25微米分辨率).
    • 使用小型化的数据接口进行8倍并行板操作 (768个井).
    • 采用基于电场的多频测量,每15分钟捕获>20个活细胞参数.

    主要成果:

    • 描述了16种不同的细胞类型,包括初级上皮细胞和悬浮细胞.
    • 在混合表皮和介质细胞共同培养中的量化异质性.
    • 选了904种化合物,确定了25种不同的作用机制 (MOA) 反应.

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    结论:

    • 半导体平台提供可扩展的,高分辨率的实时实时活细胞阻抗成像.
    • 该平台可以捕获功能参数,用于表型药物发现.
    • 这项技术增强了高通量MOA分析和药物发现应用.