相关实验视频

Updated: Jul 26, 2025

An Aptamer-based Sensor for Unchelated GadoliniumIII

An Aptamer-based Sensor for Unchelated GadoliniumIII

Published on: January 9, 2017

工程连接物稳定水素记者用于磁共振成像

Jason Yun¹, Logan Baldini², Yimeng Huang¹

¹Department of Chemistry, University of California, Santa Barbara, CA 93106, USA.

bioRxiv : the preprint server for biology

|June 19, 2023

概括

研究人员开发了LSAqp1,一种新的MRI记者,用于在活组织中进行无背景基因表达成像. 这种工程蛋白允许在体内对转基因表达进行药物导入的多重成像.

科学领域:

生物技术是生物技术.
分子成像学分子成像学
生物物理学的生物物理.

背景情况:

在活体组织中检测转基因表达需要与磁共振成像 (MRI) 等深度透成像模式兼容的记者.
现有的方法经常与背景信号作斗争,限制了特异性和动态范围.

结论:

通过将水扩散物理与蛋白质稳定性控制相结合,LSAqp1为准确的体内基因表达测量提供了一种新的方法.
这项技术增强了特异性,并使不同细胞类型的同时成像成为可能.

更多相关视频

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

相关概念视频

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

Aquaporins

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...