微生物衍生的胆酸甲基酸及其表抑制了 Clostridioides difficile 的生长和致病性,同时保护了肠道微生物群的成员
Samantha C Kisthardt1, Rajani Thanissery1, Colleen M Pike1
1North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology, Raleigh, NC.
bioRxiv : the preprint server for biology
|June 19, 2023
概括
新型胆汁酸表皮体,隔离醇酸 (iLCA) 和隔离醇酸 (iaLCA),显示强大的抑制对抗Clostridioides difficile (C. diff). 这些化合物针对C. diff的生长和毒性,同时保护有益的肠道微生物,提供了一个有前途的治疗策略.
科学领域:
- 微生物学和免疫学
- 胃肠病学 胃肠病学
- 药物发现 药物发现 药物发现
背景情况:
- 抗生素的使用破坏了肠道微生物群,减少了保护性的二次胆酸,增加了对Clostridioides difficile感染 (CDI) 的易感性.
- 石墨烯酸 (LCA) 和其表分离石墨烯酸 (iLCA) 显示出对C. difficile的抑制活性,但机制仍然不完全理解.
- 在保护肠道微生物群的同时准C. difficile对于有效的CDI治疗至关重要.
结论:
- 液CA表皮,特别是iLCA和iaLCA,是有效的抑制C. difficile的.
- iLCA和iALCA对C. difficile有不同的作用机制,包括膜损伤和减少毒素表达.
- 这些胆酸表皮体代表了CDI的有希望的治疗候选者,提供向的C. difficile抑制,同时保留肠道微生物群.
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