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Updated: Jul 26, 2025

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结合GWAS和单细胞转录组学,揭示了肠-大脑相互作用障碍的潜在基因和细胞类型

Alireza Majd1, Mikayla N Richter1, Ryan M Samuel1

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA.

medRxiv : the preprint server for health sciences
|June 19, 2023
PubMed
概括

这项研究使用了英国生物银行数据来识别与肠-大脑相互作用障碍相关的基因. 这些基因在肠道神经元中表达,揭示了特定的细胞类型和参与这些常见胃肠道疾病的分子通路.

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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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