临床特征与急性升高的眼内压力相关,后内内抗VEGF注射
Stephen A LoBue1,2, Sofya Gindina2, Nicholas J Saba2
1Department of Ophthalmology, Acuity Eye Group, Pasadena, CA, USA.
Clinical ophthalmology (Auckland, N.Z.)
|June 19, 2023
概括
内注射抗VEGF药物可能会导致眼内压力 (IOP) 暂时升高,特别是在患有青光眼病史的患者中. 建议仔细选择针头,以管理这些在抗VEGF治疗后的急性压力变化.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 抗VEGF药物的静脉内注射 (IVI) 是各种视网膜疾病的标准治疗方法.
- 在IVI后监测眼内压力 (IOP) 对患者的安全至关重要.
- 在IVI之后可能会出现急性IOP峰值,需要进一步调查.
研究的目的:
- 为了评估抗VEGF IVI对眼内压力 (IOP) 的影响.
- 为了确定与IVI后急性IOP峰值相关的因素.
- 评估干预措施的必要性,例如前腔体 (ACP).
主要方法:
- 一项前性,为期三个月的研究,涉及617名因糖尿病视网膜病变,AMD或RVO而接受IVI治疗的患者.
- 在注射前和注射后,每隔10分钟至50分钟,测量内压力.
- 如果IOP超过35mmHg在30分钟内,则进行前腔透术 (ACP).
主要成果:
- 17名患者 (2.8%) 需要ACP,在该组的基线内血压较高 (24 ± 7 mmHg vs. 16 ± 4 mmHg).
- 青光眼病史和更高的注射前内血压 (>25 mmHg) 与ACP相关.
- 与30度针相比,使用31度针与更大的内血压增加有关.
结论:
- 在IVI后的IOP峰值很常见,但通常是短暂的,在一个小时内消失.
- 患有青光眼病史和注射前IOP升高的患者可能面临更高的风险,因为使用较小尺寸的针头,可能会出现长时间的IOP尖峰.
- 建议在高风险患者中考虑针标尺,以减轻显著的内血压升高.
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