儿童烧伤后心脏代谢疾病风险标志物增加
Sofina Begum1,2,3,4,5, Samantha Lodge4, Drew Hall4
1Harvard Medical School, Harvard University, Boston, MA, United States.
Frontiers in public health
|June 19, 2023
概括
儿童烧伤幸存者表现出持久的"代谢记忆",免疫和代谢功能发生改变,增加长期心血管疾病的风险. 这凸显了持续监测儿童心脏代谢健康状况的必要性.
科学领域:
- 儿科医学 儿科医学 儿科医学
- 代谢学 代谢学 代谢学
- 免疫学 免疫学 免疫学
背景情况:
- 儿科烧伤导致显著的,长期的系统生理和代谢障碍.
- 儿童烧伤后的精确代谢轨迹和长期健康结果仍然不完全理解.
研究的目的:
- 为了全面评估儿科烧伤的慢性免疫代谢后果.
- 为了识别特定的代谢特征和经过烧伤创伤多年后持续存在的改变途径.
主要方法:
- 采用多平台策略,使用1H核磁共振 (NMR) 光谱分析血代谢物,脂蛋白和细胞因子.
- 从36名儿科烧伤幸存者 (年龄在4-8岁) 和21名健康对照者收集了血样本,受伤后3年.
- 利用代谢物相关网络分析来探索免疫和代谢标记之间的相互关系.
主要成果:
- 烧伤幸存者表现出高血糖,高代谢和炎症的特征,影响葡萄糖分解,TCA循环和氨基酸/尿素代谢.
- 观察到脂蛋白形状的显著变化,包括减少了非常低密度脂蛋白子组件和增加了小密度低密度脂蛋白颗粒.
- 在烧伤儿童中,细胞因子,脂蛋白和代谢物之间的相关性显著增加,这表明免疫代谢网络受到干扰.
结论:
- 儿科烧伤创伤建立了一个持久的持续性伤害.
- 代谢记忆的代谢记忆
- 具有相互关联的免疫和代谢失调的特征.
- 这些慢性代谢变化,无论烧伤严重程度如何,都与心血管疾病的长期风险增加有关.
- 强调儿童烧伤幸存者加强长期心脏代谢健康监测的必要性.
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