多菌株益生菌通过调整小鼠的微生物群,血清素和短链脂肪酸来缓解洛佩拉胺诱导的便秘
Jin-Ju Jeong1, Raja Ganesan1, Yoo-Jeong Jin2
1Institute for Liver and Digestive Disease, Hallym University, Chuncheon, Republic of Korea.
Frontiers in microbiology
|June 19, 2023
概括
这项研究研究了多菌株益生菌对小鼠胺诱导的便秘的影响. 益生菌显著改善了胃肠道通道和增加了便颗粒,这表明它对便秘有潜在的治疗作用.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 便秘是全球普遍存在的胃肠道疾病之一.
- 益生菌被认为具有缓解便秘症状的潜力.
研究的目的:
- 评估多菌株益生菌配方 (Consti-Biome) 在小鼠模型中改善洛佩拉胺诱导的便秘的疗效.
- 调查潜在的机制,包括对肠道传输的影响,基因表达,代谢物概况和肠道微生物群组成.
主要方法:
- 洛佩拉胺被给予大鼠以诱导便秘.
- 小鼠接受了不同度的Consti-Biome (一种混合*Lactobacillus plantarum*,*Lactobacillus rhamnosus*,*Bifidobacterium animalis*亚种的混合物. 乳腺菌,乳杆菌酸性和菌株热性) 或杜尔科拉克斯-S14天.
- 分析了胃肠道过渡率,便颗粒数,血清素和粘素基因的结肠mRNA表达,结肠血清素水平,便代谢物和便微生物群组成.
主要成果:
- 与洛佩拉胺诱导便秘组相比,多菌株益生菌显著增加了便颗粒数量和改善了胃肠道过境率.
- 益生菌治疗导致结肠中血清素和粘素相关基因的mRNA表达增加,以及结肠血清素水平升高.
- 在接受益生菌治疗的群体中,观察到代谢物的显著变化,包括短链脂肪酸的增加,以及 * Verrucomicrobia * , * Erysipelotrichaceae * 和 * Akkermansia * 的丰度增加.
结论:
- 多菌株益生菌配方有效地缓解了小鼠的洛佩拉胺诱导的便秘.
- 治疗效果很可能通过调节短链脂肪酸生产,血清素和粘素水平以及改善肠道微生物群平衡来调节.
- 这些发现强调了特定益生菌组合作为治疗便秘的治疗策略的潜力.
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