质亡相关的风险评分预测了预后,并描述了结肠腺癌瘤中的瘤微环境
Jinyan Wang1, Zhonghua Tao1, Biyun Wang1
1Department of Breast and Urologic Medical Oncology, Shanghai Medical College, Fudan University Shanghai Cancer Center, Shanghai, China.
Frontiers in oncology
|June 19, 2023
概括
与cuproptosis相关的基因 (CRG) 显著影响结肠腺癌 (COAD) 的进展和瘤微环境 (TME). 一个新的CRG风险评分系统有助于预测患者的预后,并指导个性化的COAD疗法.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 铜,一种依赖铜的细胞死亡,与癌症的发展有关.
- 在结肠腺癌 (COAD) 瘤微环境 (TME) 中,与cuproptosis相关的基因 (CRG) 的作用尚不清楚.
研究的目的:
- 调查CRG在COAD中的功能.
- 探索CRG和TME之间的关联.
- 根据CRG开发一种COAD患者的预后模型.
主要方法:
- 使用TCGA和GEO数据集用于COAD转录组,突变和副本编号改变数据.
- 进行了差异表达,生存和相关性分析.
- 员工共识无监督集群,GSVA,ssGSEA,LASSO,以及子类型和风险评分构建的Cox回归.
- 使用RT-qPCR和IHC验证的关键基因表达.
主要成果:
- 在COAD中确定了CRG的常见遗传和转录变异.
- 根据CRGs将COAD患者分为三个分子和三个基因亚型.
- 开发了一个7基因CRG风险评分系统,GLS,NOX1,HOXC6,TNNT1和PLA2G12B被验证为关键预后因素.
- 高CRG风险得分与MSI-H,TMB,CSC指数,肌/免疫得分,药物敏感性和改善的生存率相关.
- 为临床应用构建了一个名图.
结论:
- CRGs与TME,临床病理特征和COAD的预后有显著的关联.
- CRG风险评分系统为预测COAD患者的结果提供了洞察力.
- 这些发现支持基于CRG配置文件的COAD个性化治疗策略.
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