癌症阶段分离的全球景观和研究趋势:一个文献计量分析和可视化
Mengzhu Li1,2,3,4,5, Yizhan Zhang1,2,3,4,5, Jiajun Zhao2,3,4,5
1Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, China.
Frontiers in oncology
|June 19, 2023
概括
这份图书统计分析显示,癌症分相研究正在迅速发展. 未来的趋势集中在瘤微环境,免疫疗法和开发新型癌症治疗方法的预后.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 阶段分离,生物分子凝聚成无膜结构的过程,越来越多地被认为是它在各种瘤过程中的作用.
- 了解癌症的致病机制需要研究新的生物概念,如相分离.
- 这项研究解决了相位分离相关的癌症研究中图书统计数据的缺乏.
研究的目的:
- 进行对癌症相分离研究的文献分析.
- 识别出版趋势,主要贡献者和在该领域具有影响力的期刊.
- 揭示未来的研究前沿和癌症分离阶段的新兴热点.
主要方法:
- 从2009年到2022年,在Web of Science核心集合 (WoSCC) 中进行文献搜索.
- 使用VOSviewer和Citespace软件进行统计分析和可视化,对264篇出版物的分析.
- 分析了包括出版物数量,引用,组织,国家,期刊和作者在内的图书统计指标.
主要成果:
- 总共有264个出版物被确定,显示每年出版物和引用的增加趋势.
- 美国和中国在出版方面领先,中国科学院大学是最活跃的机构.
- 确定的主要研究热点包括瘤微环境,免疫疗法,预后,p53和细胞死亡.
结论:
- 癌症相分离研究是一个快速扩展的领域,具有有前途的未来.
- 虽然存在机构合作,但作者层面的合作是有限的,没有一个作者主导该领域.
- 未来的研究应该专注于相隔,瘤微环境和免疫治疗之间的相互作用,以获得新的治疗策略.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Survival Analysis
402
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
402
Cancer
48.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.8K
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K


