微生物组与宿主相互作用在阿尔茨海默氏症发展中的作用
Christian Weber1, Alexander Dilthey1, Patrick Finzer1
1Institute of Medical Microbiology and Hospital Hygiene, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Frontiers in cellular and infection microbiology
|June 19, 2023
概括
阿尔茨海默氏症可能与口腔微生物组失调有关,其中像 Porphyromonas gingivalis 这样的病原体会导致炎症和潜在的脑部感染. 本综述探讨了传染性假设和乳酸铁素.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 阿尔茨海默病 (AD) 是导致痴呆的主要原因,通常归因于β-粉样蛋白和tau病理.
- 虽然粉样蛋白向疗法显示出希望,但阿尔茨海默病中粉样蛋白聚合的根本原因尚不清楚.
- 新出现的证据表明,传染病原体和炎症在AD病因学中起着重要作用.
研究的目的:
- 审查阿尔茨海默病的传染性假设,重点关注口腔微生物组的作用.
- 探索口腔失生症, Porphyromonas gingivalis 和AD病变发生过程中的神经炎症之间的联系.
- 讨论在大脑中检测微生物的挑战,并介绍乳酸铁素作为潜在的治疗点.
主要方法:
- 在AD患者的脑脊液和脑组织中研究微生物的研究文献综述.
- 分析有关口腔微生物组合,失生症及其与全身炎症相关的研究.
- 对 Porphyromonas gingivalis 的研究和其从口腔到神经系统的潜在转移进行了审查.
主要成果:
- 在阿尔茨海默病患者中已经检测到各种微生物,包括 Porphyromonas gingivalis 和 Spirochaetes.
- 口腔病理和失生症与可能促进微生物转移的亲炎症状态有关.
- 乳酸被认为是异生物微生物组和宿主炎症反应之间的潜在调解者.
结论:
- 口腔微生物组失生症是阿尔茨海默氏症发展的一个合理的贡献者.
- 传染病原体和炎症,特别是来自口腔的炎症,需要进一步调查AD的病因因素.
- 针对口腔微生物组和相关的炎症途径,可能使用乳酸等药物,可能为AD提供新的治疗策略.
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