在接受歇斯底里镜检查的患者中,用于镇静/麻醉的西普罗的有效性和安全性:随机,并行组,受控试验
Haiyan Lan1, Weifeng Shan1, Yini Wu1
1Department of Anesthesiology, Lishui City People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, People's Republic of China.
Drug design, development and therapy
|June 19, 2023
概括
与propofol相比,西普罗在透镜中提供了一种更安全的镇静选择. 这项研究发现,西普罗会导致较少的不良事件,包括注射疼痛和呼吸问题,同时保持高的成功率.
科学领域:
- 麻醉学 麻醉学
- 妇科手术 妇科手术
背景情况:
- 腹膜镜检查需要有效的镇静剂,以确保患者的舒适性和程序的成功.
- 普罗波是一种常用的麻醉剂,但可能与不良反应有关.
研究的目的:
- 为了比较西普罗福尔与普罗波福尔在催产镜检查期间镇静的疗效和安全性.
- 为了评估血液动力学稳定性,呼吸功能和在西普罗福尔或普罗福尔镇静下进行透镜检查期间的患者舒适度.
主要方法:
- 149名接受透镜检查的患者被随机分配给接受西普罗福或普罗波福的镇静剂.
- 两组都接受了sufentanil作为止痛药;使用BIS值监测镇静深度.
- 结果包括透镜成功率,血液动力学变化,不良事件,注射疼痛和恢复时间.
主要成果:
- 在西普罗和普罗波组中,透镜成功率为100%.
- 与普罗相比,西普罗的低血压,呼吸系统不良事件,注射疼痛和身体运动发生率显著降低.
- 在唤醒时间,麻醉师满意度或恶心/吐率方面没有发现显著差异.
结论:
- 齐普罗是一种比普罗波更安全的替代品,用于透镜镇静.
- 西普罗比普罗波具有优势,包括减少注射疼痛,减少血液动力学影响和减少呼吸抑制.
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