香香对大鼠实验诱导结石的影响
Mohamed S Al-Marhoon1, Ahmed Al-Harrasi2, Khurram Siddiqui1
1Urology Division, Department of Surgery, College of Medicine and Health Sciences Sultan Qaboos University Seeb Sultanate of Oman.
BJUI compass
|June 19, 2023
概括
香,也被称为卢班,有效地治疗和预防老鼠的结石. 最高剂量150 mg/kg/day显著逆转了引起结石的影响,改善了脏组织的健康状况.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 自然产品 自然产品
背景情况:
- 香 (卢班),来自*Boswellia sacra*,具有已知的药用特性.
- 卢班的抗炎和治疗潜力正在获得科学关注.
- 尿病,或结石疾病,影响了人口的很大一部分.
研究的目的:
- 研究卢班水提取物及其精油在实验诱导结石的小鼠模型中的疗效.
- 评估卢班对尿病的治疗和预防作用.
主要方法:
- 通过使用*trans*-4-hydroxy-L-proline (HLP) 来诱导尿病的老鼠模型.
- 大鼠接受了不同剂量的Luban (50,100,150毫克/公斤/天) 或Uralyt-U (标准治疗) 治疗.
- 分析了血生物化学参数和组织学,以评估治疗结果.
主要成果:
- 150毫克/公斤/天的卢班剂量显著逆转了HLP诱导的光质效应,包括尿氧酸和血尿酸的升高.
- 组织学检查显示,在最高的Luban剂量下,氧酸盐晶体形成和管状缩等组织损伤的改善.
- 卢班在治疗和预防结石方面表现出显著的改善.
结论:
- 卢班对大鼠实验诱导的结石具有显著的治疗和预防作用.
- 确定的最佳有效剂量为150mg/kg/天.
- 建议对人类受试者和其他动物模型进行进一步的研究,以验证这些发现.
关键词:
博斯韦利亚 Boswellia 博斯韦利亚卢班·卢班 (Luban Luban) 是一个古老的语言.弗兰金香是一种香料.脏 脏 脏是什么?鼠类 鼠类 鼠类 鼠类 鼠类脏 脏的 脏这些石头是石头.更多相关视频
06:46Author Spotlight: Understanding the Effect of Herbal-Cake-Separated Moxibustion in Rats with Renal Faliure
Published on: December 22, 2023
820
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
613
相关概念视频
01:30Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
11
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
16
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
16
01:28Urinary Tract Calculi I: Introduction
19
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
19
01:28Urinary Tract Calculi V: Nursing Management
14
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
14
01:25Urinary Tract Calculi VI: Surgical Management
11
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
11