在怀孕期间与瘤相关的抗N-甲基D-酸盐受体脑炎
Mridul Bansal1, Aryan Mehta1, Anand Karthik Sarma2
1Section of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
概括
一名孕妇因抗N-甲基-D-酸盐受体脑炎而经历了急性精神病. 治疗包括为卵巢瘤进行手术,导致她神经症状的部分改善.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 妇科 妇科 妇科 妇科
背景情况:
- 一名36岁的怀孕妇女有抑郁病史,出现了急性精神病,幻觉和迷失方向.
- 最初的评估包括正常的神经和CT扫描,导致诊断急性精神病和兴奋妄想.
- 患者对高剂量的抗精神病药物没有反应,需要身体限制.
研究的目的:
- 为了调查孕妇患者急性精神病的潜在原因,孕妇患者对传统治疗没有反应.
- 为了确定潜在的自身免疫或神经瘤病因,导致严重的神经精神症状.
主要方法:
- 进行脑脊液 (CSF) 分析以排除感染,并测试特定抗体.
- 进行腹部成像,以确定任何潜在的潜在瘤.
- 患者接受了切除卵巢囊的手术.
主要成果:
- 脑脊液分析显示存在抗N-甲基-D-酸盐受体 (NMDAR) 抗体,证实了自身免疫性脑炎.
- 一个卵巢囊被确定并通过手术切除 (卵巢切除术).
- 手术后,患者出现间歇性动荡发作,需要继续服用抗精神病药物.
结论:
- 抗N-甲基-D-酸盐受体脑炎可以在孕妇中出现严重的精神病.
- 卵巢瘤是NMDAR脑炎的常见原因,手术切除可以成为管理的关键部分.
- 虽然治疗改善了症状,但需要持续监测和管理.
更多相关视频
10:19High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
16.3K
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.4K
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Antiepileptic Drugs: Glutamate Antagonists
435
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
435
