作为甲状腺瘤癌的预后因素,复发时间
Felipe Ferraz Magnabosco1, Marilia D'Elboux Guimarães Brescia1, Climério Pereira Nascimento Júnior1
1Division of Head and Neck Surgery, LIM-28, Laboratorio de Cirurgia de Cabeca e Pescoco, Hospital das Clínicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 05403-000, Brazil.
Journal of the Endocrine Society
|June 19, 2023
概括
副甲状腺癌 (PC) 很少见,但患者可以存活数十年. 在最初的手术中实现自由边缘对于更好的结果至关重要,因为复发会影响生存率.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 副甲状腺癌 (PC) 是一种罕见的内分泌恶性瘤,预后因素不明确.
- 了解患者的特征和治疗结果对于改善管理策略至关重要.
研究的目的:
- 随着时间的推移,分析治疗副甲状腺癌的患者的特征.
- 为了确定影响副甲状腺癌患者结果的预后因素.
主要方法:
- 对手术治疗副甲状腺癌患者的回顾性队列研究 (2000-2021年).
- 对人口,临床,实验室,手术,病理和随访数据的评估.
- 专注于怀疑恶性瘤的自由边缘切除.
主要成果:
- 分析了17名患者;60%的人经历了复发 (区域性,远程或两者兼而有之).
- 自由边际至关重要;在36个月内复发显著降低了生存率.
- 瘤分期系统和瘤大小没有预测死亡率;块切除没有提供任何优势.
结论:
- 副甲状腺癌可以有一个惰的过程,可能有长期的生存.
- 在初始手术期间实现自由边缘是预后最关键的因素.
- 早期复发 (<36个月) 与较差的整体存活率有关.
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