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临床医生对儿童脂质查的反应表明严重的脂质失调症
Amy W Zawacki1, Connor Enright1, Rachel E Harris2
1Department of Pediatrics, Division of Pediatric Cardiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
The journal of pediatrics: X
|June 19, 2023
概括
临床医生记录了69%的严重儿科失脂症病例在30天内采取的行动. 全球查有效地识别严重的儿科脂质失调症 (非高密度脂蛋白胆固醇≥190 mg/dL),需要改进的管理方案.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 临床脂质学 临床脂质学
- 公共卫生 公共卫生
背景情况:
- 严重的儿科失脂症,定义为非高密度脂蛋白胆固醇 (HDL-C) ≥190 mg/dL,构成早期心血管疾病的风险.
- 建议对儿童进行全方位的脂质查,但坚持不一致.
- 对重症儿科失脂症查结果的临床反应尚不清楚.
研究的目的:
- 评估严重儿科血脂不良症的病例检测和反应时间.
- 为了分析临床医生在认定严重的儿科血脂不良症后采取的行动.
- 确定在患有严重脂质失调症的儿童中进行脂质查的指示.
主要方法:
- 从2010年1月到2018年6月,对16860个儿科脂质面板 (年龄在0-18岁) 的回顾性审查.
- 对非HDL-C ≥190 mg/dL的患者进行图表审查,以评估查指示,临床专业,采取的行动和采取行动的时间.
- 对已记录的诊断进行分析.
主要成果:
- 1.1% (178名患者) 患有严重的脂质障碍症 (非高血压水平-C ≥190毫克/分升).
- 普遍查是最常见的指示 (52%).
- 47%的病例在7天内,69%的病例在30天内记录了临床反应;18%的病例没有记录后续治疗.
- 家族性高胆固醇血症是最常见的诊断 (24%).
结论:
- 大多数严重的儿科失脂症病例都得到了一些临床医生的行动,尽管行动有所不同.
- 全球查是检测严重儿科失脂症的重要方法.
- 需要改善教育和管理方案,以提高临床医生对高风险儿童严重儿科失脂症的反应.
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