在患有1型糖尿病的儿童和青少年中查脂质和功能:年龄是否重要?
Eulalia Catamo1, Antonietta Robino1, Klemen Dovc2,3
1Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, Trieste, Italy.
Frontiers in endocrinology
|June 19, 2023
概括
失脂症和脏问题在患有1型糖尿病的年轻人中很常见. 早期查糖尿病并发症对于所有儿童和青少年至关重要,无论年龄或疾病持续时间如何.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 儿童群体的1型糖尿病 (T1D) 管理需要对长期并发症进行监测.
- 脂质特征异常和功能下降是患有慢性疾病的青少年的重大问题.
研究的目的:
- 为了评估失脂症的患病率和评估诊断为1型糖尿病的儿童和青少年的功能.
- 在这个队列中,确定脂质配置文件,功能标志物和临床因素之间的关联.
主要方法:
- 对324名患有T1D的儿科患者进行了回顾性分析.
- 收集人口统计,临床数据和生化标志物,包括脂质资料和功能指标.
- 多变量回归分析以确定失脂血症和功能的预测因子.
主要成果:
- 观察到显著的血脂不良的患病率 (32%在<11年,18.5%在≥11年),与较小的儿童高的甘油三水平.
- 虽然专蛋白与肌素的比率保持在正常水平,但17%的估计膜过率 (eGFR) 略有下降.
- 糖化血红蛋白 (HbA1c) 水平与总胆固醇,LDL胆固醇,HDL胆固醇和eGFR密切相关.
结论:
- 脱脂症在患有T1D的儿科年龄组中普遍存在,需要年龄独立的查.
- 早期发现和管理糖尿病并发症,包括脂质和脏异常,对于优化患者的治疗结果至关重要.
- 建议加强血糖控制和量身定制的营养治疗以减轻风险.
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