甲基乙烯的内分泌干扰和致癌作用
Yi Wang1, Xinpei Wang1,2, Shaofeng Sui3
1Department of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in endocrinology
|June 19, 2023
概括
脱博乙烯 (BDE209) 暴露可能会影响甲状腺功能,并可能导致甲状腺癌. 需要进一步的研究来澄清BDE209的确切机制.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 作为一种广泛使用的阻燃剂,甲基乙烯 (BDE209) 在人体血清中的含量正在增加.
- 由于BDE209与甲状腺激素的结构相似,人们对其内分泌干扰潜力表示担忧.
- 由于其在环境中普遍存在,研究BDE209的甲状腺毒性至关重要.
研究的目的:
- 审查和综合现有的关于BDE209对内分泌系统的不良影响的文献,重点是甲状腺.
- 评估BDE209在甲状腺癌发展中的潜在作用.
- 为了确定有关BDE209甲状腺毒性途径的知识差距.
主要方法:
- 在PubMed数据库中进行了全面的文献搜索.
- 关键词包括"BDE209", "decabromodiphenyl以太", "内分泌干扰", "甲状腺" 和 "致癌".
- 研究是根据其强调BDE209对内分泌系统的不良影响而选择的,重点是甲状腺影响.
主要成果:
- 从最初的748个研究中选择了45个研究.
- 通过多种机制,BDE209可能会影响甲状腺功能和甲状腺癌瘤发生.
- 潜在的途径包括干扰甲状腺激素受体 (TR),下丘脑-垂体-甲状腺 (HPT) 轴,酶活性和甲基化.
结论:
- 虽然BDE209对甲状腺功能的毒性影响已有证据,但其在甲状腺瘤发生中的作用需要进一步研究.
- 通过BDE209发挥甲状腺毒性的确切途径尚未确定.
- 需要进行更多的研究才能充分了解BDE209的致癌潜力及其机制.
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