在患有赤色皮肤牛皮的患者中进行心血管疾病诊断的nomogram
Yue-Min Zou1, Dong-Mei Zhou2, Man-Ning Wu1
1Beijing University of Chinese Medicine, Beijing, China.
Frontiers in immunology
|June 19, 2023
概括
皮质皮质牛皮患者面临更高的心血管疾病风险. 关键指标包括年龄,糖性白蛋白,吸烟,白蛋白水平和脂蛋白,有助于风险预测.
科学领域:
- 皮肤病学和心脏病学
- 临床研究 临床研究
- 生物统计学 生物统计学
背景情况:
- 红皮质牛皮 (EP) 与由于严重的皮肤炎症而增加心血管疾病 (CVD) 风险有关.
- 开发EP患者心血管疾病的预测模型对于风险分层和管理至关重要.
研究的目的:
- 开发和验证一种诊断模型,用于预测红皮皮质牛皮患者心血管疾病风险.
- 在EP人群中确定与心血管疾病风险相关的关键临床参数.
主要方法:
- 对298名PE患者的回顾性分析,其中213名在开发组中,85名在验证组中.
- 用于确定心血管疾病的显著风险因素的单变和逆向渐进回归.
- 使用歧视 (AUC) 和校准评估的模型性能.
主要成果:
- 开发集中的CVD率为9%.
- 心血管疾病的独立预测因素包括年龄,糖性白蛋白 (GA>17%),吸烟,白蛋白 (ALB<40 g/L) 和脂蛋白 (Lp) >300 mg/L).
- 诺米克模型在开发组中实现了0.83的AUC,在验证组中达到0.85,表明了良好的临床适用性.
结论:
- 年龄,高GA,吸烟,低ALB和高Lp (a) 是EP患者心血管疾病的重要危险因素.
- 开发的诺莫格拉姆模型有效地预测了EP患者心血管疾病风险.
- 该模型可以帮助改善心血管疾病风险的EP患者的外科手术期间的策略和治疗结果.
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