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大脑衍生的神经营养因子Val66Met多态度缓解了大学生冲动性,负面情绪和饮酒强度之间的关系

Farid Benzerouk^1,2,3,4, Fabien Gierski^1,2,3,4, Séverine Lannoy⁵

¹University of Reims Champagne-Ardenne, 51100 Reims, France; Cognition Health Society Laboratory (C2S-EA 6e291), 51100 Reims, France.

Alcohol and alcoholism (Oxford, Oxfordshire)

|June 19, 2023

概括

大脑衍生神经营养因子 (BDNF) 基因的遗传变异通过影响年轻成年人的冲动性和情绪调节来影响过度饮酒 (BD). 这项研究突出了特定的BDNF rs6265多态关系与BD脆弱性因素.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
精神病学是一个精神病学.

背景情况:

过度饮酒 (BD) 是年轻成年人中普遍存在的问题.
导致BD及其相关特征的遗传因素尚未得到充分研究.
大脑衍生神经营养因子 (BDNF) 基因是酒精使用障碍的候选基因.

研究的目的:

在年轻成年人中检查冲动性,情绪调节和BD之间的关联.
调查BDNF rs6265/Val66Met变异在这些关联中的作用.
为了确定BD的遗传脆弱性因素.

主要方法:

对226名大学生 (年龄在18-25岁) 的横截面研究.
评估酒精消费,抑郁,焦虑,冲动性 (UPPS-P) 和情绪调节 (DERS).
使用基于BDNF基因型的部分相关性和适度分析进行分析.

主要成果:

在Val/Val基因型中,BD得分与缺乏预谋和感觉寻找相关.
在MET携带者中,BD得分与积极的紧迫性,缺乏预谋,缺乏力,感觉寻求和情绪调节清晰度相关.
BDNF Val/Met基因型调节了临床变量和BD之间的关系.

结论:

在BDNF rs6265多态性影响易受暴饮的脆弱性.
与冲动性和情绪调节相关的常见和特定因素与基于BDNF基因型的BD相关.
这些发现有助于理解BD的遗传基础.

关键词:

滥用酒精滥用酒精滥用酒精滥用酒精调节分析,调节分析.部分相关性分析,部分相关性分析.漏洞的脆弱性漏洞的脆弱性年轻的成年人年轻的成年人

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