[与艾滋病毒治疗相关的睡眠障碍.]
Manuel Vélez-Díaz-Pallarés1, Beatriz Esteban-Cartelle1, Teresa Gramage-Caro1
1Servicio de Farmacia, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid. España.
Revista espanola de salud publica
|June 19, 2023
概括
整合酶抑制剂,如比克特格拉维尔和杜洛特格拉维尔是常见的艾滋病毒治疗方法. 这项研究发现,服用这些药物的患者和服用其他艾滋病毒药物的患者之间睡眠质量没有显著差异.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
背景情况:
- 综合酶抑制剂是推的第一线HIV治疗.
- 一些整合酶抑制剂可能会导致中枢神经系统的副作用,包括睡眠障碍.
研究的目的:
- 调查比克特格拉维尔和多卢格拉维尔对艾滋病毒患者睡眠质量的影响.
- 为了比较服用比克特格拉维尔或多卢特格拉维尔的患者的睡眠质量与其他艾滋病毒治疗方法.
主要方法:
- 这是一项对119名艾滋病毒患者的观察性,横截面研究.
- 使用匹兹堡睡眠质量问卷 (PSQI) 评估睡眠质量.
- 根据比克特格拉维尔/多卢格拉维尔使用 (研究) 与其他治疗 (对照) 进行分组的患者.
主要成果:
- 睡眠障碍的高患病率 (64%的研究组,67%的对照组) 无论如何治疗.
- 总体睡眠质量 (p=0.788) 或特定睡眠组件之间没有统计学上显著的差异.
- 在使用比克特格拉维尔/多卢格拉维尔和睡眠质量降低之间没有发现相关性.
结论:
- 睡眠障碍在艾滋病毒患者中很常见,不论是否使用比克特格拉维尔或杜洛特格拉维尔.
- 目前的艾滋病毒治疗方法,包括比克特格拉维尔和多卢格拉维尔,与替代药物相比,似乎没有显著恶化睡眠质量.
- 进一步的研究可能会探索其他因素,导致这一群体的睡眠问题.
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