疹病毒对健康老年人多种认知结果的长度影响
Bodil Weidung1, Maria Josefsson2, Peter Lyttkens3
1Department of Public Health and Caring Sciences, Section of Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
Journal of Alzheimer's disease : JAD
|June 19, 2023
概括
简单疹病毒1型 (HSV-1) 抗体与老年人认知能力较差有关,影响记忆力和执行功能. 长度认知衰退与HSV-1感染无关.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 老年学是指老年学的学科.
背景情况:
- 疹病毒被认为是阿尔茨海默病的潜在可修改触发因素.
- 研究疹简单病毒1型 (HSV-1) 和细胞大脑病毒 (CMV) 在认知健康中的作用至关重要.
研究的目的:
- 检查HSV-1和CMV的血清抗体与认知结果之间的关联.
- 探索疹病毒抗体,APOE ɛ4基因型和认知表现之间的潜在相互作用.
主要方法:
- 这项研究包括来自乌普萨拉老年人血管前性调查 (PIVUS) 队列的849名老年参与者.
- 认知功能在75岁和80岁时使用MMSE,TMT A/B和7MS测试进行评估.
- 测量了HSV-1和CMV的血清抗体,以及APOE ɛ4基因定型.
主要成果:
- 抗HSV-1IgG阳性与多个认知测试的表现差相关,包括MMSE,TMT-A,TMT-B和口语流.
- 对抗CMVIgG没有发现横截面关联,尽管随着时间的推移,TMT-B得分在携带者中下降了更多.
- 观察到抗HSV-1 IgG和APOE ɛ4之间的相互作用,以及抗HSV IgM,APOE ɛ4和治疗之间的相互作用,影响特定的认知领域.
结论:
- 在认知健康的老年人中,HSV-1感染与较差的认知功能有关,影响执行功能,记忆和语言.
- 虽然横截面认知受到了影响,但纵向认知衰退与这一队列的HSV-1阳性没有直接联系.
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