莱苏尔研究:为多模式生活方式干预研究的纵向随机对照试验协议,以减少健康老年人痴呆风险
Ciara Treacy1, Jacob M Levenstein1, Annelise Jefferies1
1Thompson Institute, University of the Sunshine Coast, Maroochydore DC, QLD, Australia.
Journal of Alzheimer's disease : JAD
|June 19, 2023
概括
这项研究调查了为期12周的生活方式干预 (运动,饮食,睡眠,正念) 以减少老年人痴呆风险. 它旨在通过针对可修改的风险因素来预防认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 痴呆症源于多种原因,包括炎症和血管问题,受可修改,生活方式驱动的风险因素的影响.
- 这些因素在长期的临床前阶段对痴呆症风险作出了重大贡献,为早期干预提供了目标.
- 高达40%的痴呆风险可归因于可修改的因素,突出显示了生活方式干预的潜力.
研究的目的:
- 概述生活方式干预研究减少痴呆风险 (LEISURE) 随机对照试验的协议.
- 评估多模式生活方式干预措施在健康老年人中降低痴呆风险的有效性.
- 研究运动,饮食,睡眠和正念对痴呆症病因发生的相互作用.
主要方法:
- 一个为期12周的随机对照试验 (RCT),涉及50-85岁的健康成年人.
- 运动,饮食,睡眠和正念的整合作为一种多模式干预.
- 6个月和24个月的长度随访,包括全面的二次结果和探索性神经成像.
主要成果:
- 详细介绍了LEISURE研究协议,包括其位于澳大利亚的位置,澳大利亚的老年人人口和痴呆症患病率很高.
- 新的包括正念和睡眠作为干预目标.
- 综合评估心理,身体,睡眠,认知,神经成像和分子测量.
结论:
- 该LEISURE试验提供了一种新的多模式方法来降低痴呆风险.
- 它的目的是提供关于大脑行为机制的见解,这些机制是痴呆症预防的基础.
- 该研究已注册,并设定评估生活方式干预的长期影响.
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