在被扰乱的体内运动过程中理解肌肉功能,使用肌肉化身方法
Nicole Rice1, Caitlin M Bemis1, Monica A Daley2
1Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.
The Journal of experimental biology
|June 19, 2023
概括
阿凡达的方法准确地模仿了体内的肌肉机制. 复制自然肌肉应变模式可以改善动态运动期间肌肉工作和力量的研究.
科学领域:
- 生物力学 生物力学
- 肌肉生理学 肌肉生理学
背景情况:
- 工作循环技术对于了解运动期间的肌肉功能至关重要.
- 现有的ex vivo方法难以复制体内肌肉活动的复杂,可变的应变速率.
研究的目的:
- 开发和验证一种"avatar"方法来进行ex vivo肌肉研究.
- 在不稳定的运行过程中,使用老鼠延伸器digitorum longus (EDL) 实体研究几内亚的侧面胃口 (LG) 肌肉机制.
主要方法:
- 在老鼠EDL肌肉上的ex vivo工作循环实验.
- 在各种运行条件下 (障碍物扰动,稳定运行) 来复制几内亚LG的体内菌株轨迹.
- 使用体内菌株轨迹与侧边形轨迹生成的力量的比较.
主要成果:
- 使用体内菌株轨迹的ex vivo力与体内LG力 (R2=0.58-0.94) 密切匹配.
- 侧面轨迹产生明显不太准确的力预测 (平均R2=0.045).
- 在体内应变模式显示了基于运动方向 (例如,上升与下降的障碍物) 的肌肉工作输出转移.
结论:
- 阿凡达方法有效地模拟了体内肌肉机制.
- 肌肉激活调整粘弹性特性,影响在时间变化的负载下产生力.
- 这种方法增强了复杂的运动行为中的肌肉动力学的研究.
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