由国际和中国指导方针的值定义的左心室缩的预后影响
Dan Zhou1, Mengqi Yan1, Anping Cai1,2
1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Journal of clinical hypertension (Greenwich, Conn.)
|June 19, 2023
概括
中国的左心室缩症 (LVH) 门比国际准则更好地预测高血压患者的死亡率. 使用特定种族的值和将左心室质量 (LVM) 索引到BSA或身高^1.7可以改善风险分层.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 医学统计 医学统计
背景情况:
- 左心室缩 (LVH) 是高血压患者死亡的重要预测因素.
- 目前关于LVH定义的国际指导方针可能不适合所有人群.
- 准确的LVH评估对于心血管风险分层至关重要.
研究的目的:
- 为了在中国高血压患者中比较由中国值和国际指导方针定义的LVH死亡率的预测值.
- 为了确定在中国人群中为LVH评估索引左心室质量 (LVM) 的最佳方法.
- 调查不同LVH定义与全因和心血管死亡率之间的关联.
主要方法:
- 分析了一组2454名社区高血压患者的队列,测量了LVM和相对壁厚.
- LVM被索引为身体表面积 (BSA),高度^2.7和高度^1.7.
- 考克斯的比例危险模型,C-统计数据和时间依赖的ROC曲线被用于评估LVH死亡率预测.
主要成果:
- 根据中国值 (LVM/BSA) 定义的LVH与心血管死亡率有显著的关联.
- 使用中国值的LVM/BSA和LVM/Height^1.7都显示出与全因死亡率的显著关联.
- 与国际准则相比,LVM/BSA和LVM/Height^1.7的中国门显示出更好的死亡率预测能力.
结论:
- 建议使用特定种族的值来对LVH进行分类,并改善中国高血压人群的死亡风险分层.
- 索引为BSA和高度^1.7的LVM是中国高血压患者LVH评估的可接受规范化方法.
- 使用适当的LVH定义和索引方法可以更好地预测高血压的不良结果.
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