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维生素D和胃癌 - - 一个系统的审查和元分析
Nutricion hospitalaria
|June 19, 2023
概括
低血清维生素D水平与更高的胃癌风险有关. 较低的维生素D也与患者的晚期癌症,差异化和淋巴结转移有关.
科学领域:
- 在瘤学瘤学.
- 营养生物化学 营养生物化学
背景情况:
- 胃癌仍然是一个重大的全球健康问题.
- 越来越多的人认为维生素D缺乏是各种癌症的潜在因素.
研究的目的:
- 研究血清维生素D水平与胃癌的发病率和病理特征之间的关联.
- 探索维生素D水平是否与胃癌的严重程度相关.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane,中国数据库) 进行了系统的文献搜索,搜索了2021年7月之前发表的研究.
- 10项涉及1159名胃癌患者和33387名对照患者的试验的元分析.
主要成果:
- 与对照组相比,胃癌患者的血清维生素D水平明显较低 (15.56 ± 7.46 ng/ml与17.60 ± 1.61 ng/ml相比).
- 较低的维生素D水平与晚期临床阶段 (III/IV与I/II),差异化瘤和淋巴结转移的存在相关.
- 在淋巴结转移和整体胃癌发生方面观察到有统计学意义的差异.
结论:
- 血清维生素D水平与胃癌有负面关联.
- 低维生素D水平可能作为胃癌预后不佳的预测标记,与临床阶段,分化和淋巴结状况相关.
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