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Updated: Jul 26, 2025

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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与智力障碍相关的O-GlcNAc转移酶致病变体影响多能干细胞自我更新

Michaela Omelková1, Christina Dühring Fenger2,3, Marta Murray1

  • 1Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Disease models & mechanisms
|June 19, 2023
PubMed
概括

与O相关的β-N-乙糖胺 (O-GlcNAc) 转移酶 (OGT) 的遗传变异导致OGT-CDG,这是一种与智力障碍相关的疾病. 一种新型的OGT变种破坏了干细胞的自我更新,为发育原因提供了洞察力.

关键词:
这就是O-GLcNAcc.葡萄糖化先天性疾病智力障碍 智力障碍是一种智力障碍.其他 OGT 产品.自我更新是一种自我更新.干细胞是一种干细胞.

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