蛋白质/多糖复合物,以实现多合一的血液中毒素去除,具有自我抗凝和生物相容性
Mengjie Li1,2,3, Mengmeng Chen1,2,3, Facui Yang4
1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.
Advanced healthcare materials
|June 19, 2023
概括
一种由酶 (LZ) 和藻酸盐 (SA) 制成的新生物相容吸附剂可以同时从血液中去除多种毒素,如胆红素,尿素,重金属和抗生素. 这一突破推动了血液输血技术的发展,用于治疗与血液有关的疾病.
科学领域:
- 生物材料科学 生物材料科学
- 生物医学工程 生物医学工程
- 材料化学 材料化学
背景情况:
- 输血需要生物相容的吸附剂来去除毒素.
- 目前的吸附剂不能同时去除各种中小分子毒素,阻碍了设备的小型化.
- 存在对高效,多功能血 perfusion 材料的需求.
研究的目的:
- 开发一种具有"多合一"毒素去除能力的新型生物相容吸附剂.
- 创建一种简单快速的方法来制备血 perfusion 吸附剂.
- 评估开发材料对各种毒素的吸附性能.
主要方法:
- 通过混合酶 (LZ) 和藻酸盐 (SA) 来制备蛋白质多糖化合物复合物.
- 吸附剂的组成和表面性能的表征.
- 使用已知方法量化胆红素,尿素,重金属 (Hg2+,Pb2+,Cu2+,Cr3+,Cd2+) 和抗生素的吸附能力.
主要成果:
- 这种LZ/SA吸附剂对胆红素 (468毫克g-1),尿素 (331毫克g-1),Hg2+ (497毫克g-1) 具有很高的吸收能力.
- 在血清白蛋白中达到创纪录的高胆红素吸附能力,模拟生理条件.
- 展示了对广泛的重金属和抗生素的有效吸附.
- 确定了各种暴露的功能组,这些功能组有助于高吸附效率.
结论:
- 一种全新的,完全生物衍生的LZ/SA吸附剂可以同时去除各种毒素.
- 简单的制备方法和多功能吸附特性具有显著的优势.
- 这种材料对血液输血和治疗血液相关疾病的应用具有很大的前景.
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