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炎症性肠道疾病的心血管表现和潜在的致病机制
Ying Xiao1,2, Don W Powell2, Xiaowei Liu1
1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, China.
概括
炎症性肠病 (IBD) 通过系统性炎症和肠道失生症增加心血管疾病的风险. 这篇评论探讨了IBD.
科学领域:
- 胃肠病学和心脏病学
- 免疫学和微生物学
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎和克罗恩病,与心血管疾病 (CVD) 风险增加有关.
- 在IBD患者中,系统性炎症,肠道失调,改变的microRNA和脂质样本有助于心脏并发症.
- 由于凝血因子和血小板活性发生变化,IBD患者患血栓的风险增加了3-4倍.
研究的目的:
- 审查IBD患者心血管疾病的患病率.
- 阐明将IBD与心血管疾病联系起来的致病机制.
- 评估IBD药物的心血管影响.
主要方法:
- 对国家队列研究和现有研究的文献综述.
- 分析分子机制,包括肠心轴.
- 检查诸如炎症,microRNAs,微生物群和血栓形成等因素.
主要成果:
- IBD是心血管疾病的独立风险因素,其机制包括炎症,氧化应激和血管变化.
- 改变的肠道微生物群和外体微RNA在心脏重塑和纤维化中起作用.
- 在IBD患者中存在动脉样硬化的诱导因素.
结论:
- 了解肠心轴对于管理IBD中的心血管疾病至关重要.
- 对分子通路的进一步研究可以导致向治疗.
- 对IBD患者来说,全面的心血管风险评估是必不可少的.
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