人类健康和疾病中的 NAD+ 前体:当前状况和未来前景
Keisuke Yaku1, Takashi Nakagawa1,2
1Department of Molecular and Medical Pharmacology, Faculty of Medicine; Toyama, Japan.
Antioxidants & redox signaling
|June 19, 2023
概括
尼古丁胺胺氨基二核酸 (NAD+) 前体如NR和NMN是安全的,并提高了人类的NAD+水平. 然而,它们的疗效低于预期,需要对新陈代谢和输送进行进一步的研究以获得最佳结果.
科学领域:
- 生物化学 生物化学
- 衰老研究研究 衰老研究
- 代谢过程中的代谢.
背景情况:
- 尼古丁胺胺二核酸 (NAD+) 是生物过程中的重要辅助因子.
- NAD+前体在打击与年龄相关的衰退方面表现有前途,得到了广泛的临床前数据的支持.
- 临床试验越来越多地研究NAD+前体,特别是尼古丁胺基核糖胺 (NR) 和尼古丁胺基 mononucleotide (NMN).
研究的目的:
- 审查目前关于人体内NAD+前体的管理的证据.
- 探索NAD+代谢的复杂性,包括宿主肠道微生物群的相互作用.
- 确定未来研究领域,以优化NAD+前体的有效性和输送.
主要方法:
- 对NAD+前体 (NR和NMN) 的临床前期和临床研究的综述.
- 对NAD+代谢和肠道微生物群的作用的数据分析.
- 检查NAD+补充研究中的挑战和未来方向.
主要成果:
- 口服NR和NMN是安全的,并增加人类的NAD+水平.
- 目前,NAD+前体的临床疗效低于从临床前发现中预期的.
- 主体-肠道微生物群相互作用显著影响NR和NMN代谢.
结论:
- 进一步的临床研究对于确定NAD+前体在人类中的有效性至关重要.
- 需要更好地了解体内NAD+代谢,以优化补充策略.
- 开发针对NAD+前体的向输送方法对于改善临床试验结果至关重要.
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