开发由植物甘油原衍生的核心--冠冕纳米颗粒,并与联的林诺酸复合
Ziqi Wang1, Xiuting Hu1, Bruce R Hamaker1,2
1State Key Laboratory of Food Science & Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, P. R. China. miaoming@jiangnan.edu.cn.
Food & function
|June 19, 2023
概括
与自组装的纳米颗粒相比,酶组装的植物甘油素纳米颗粒提供了更好的保护和交付合利诺基酸 (CLA). 这种新型载体平台显示出水生物活性成分的向输送潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 营养保健品 营养保健品
背景情况:
- 结合烯酸 (CLA) 是一种具有治疗潜力的有价值的生物活性成分.
- 需要有效的输送系统来保护CLA免受氧化,并确保有针对性的输送.
- 植物甘油素是一种天然的多糖,为开发新型纳米粒子载体提供了机会.
研究的目的:
- 为了制造和表征植物糖原衍生纳米颗粒用于CLA输送.
- 为了比较自组装 (SMPG/CLA) 和酶组装 (EMPG/CLA) 纳米颗粒的性能.
- 评估这些纳米粒子系统中CLA的保护作用和释放概况.
主要方法:
- 用CLA.制造自组装和酶组装的植物甘油素-纳米粒子复合体.
- 确定最佳的主机-客户比率,装载率和产量.
- 使用评估空间架构和结晶性的技术进行结构性表征.
- 在体外评估CLA对氧化和模拟胃肠道消化的保护.
主要成果:
- 在SMPG/CLA和EMPG/CLA复合体中实现了最佳的1:10比.
- 与SMPG/CLA相比,EMPG/CLA的装载率 (1.6%) 和收益率 (88.1%) 更高.
- 由于更有序的晶体结构,EMPG/CLA证明了对CLA氧化的增强保护.
- 在1小时消化后,EMPG/CLA的CLA释放率较低 (58.7%),而SMPG/CLA (73.8%).
结论:
- 植物糖原纳米颗粒的 in situ 酶组合为CLA输送提供了一个卓越的平台.
- 该EMPG/CLA系统提供了加强保护和控制释放的疏水生物活性成分.
- 来自植物甘油素的纳米颗粒显示出在营养品和药品中有望用于有针对性的输送应用.
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