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对强迫症患者的增强剂的临床建议 强迫症患者对色素再吸收抑制剂有部分反应
1From the Beaumont Psychiatry, Beaumont Health, Southfield; Department of Psychiatry; Michigan State University, East Lansing; Wayne State University, Detroit; Oakland University William Beaumont, Dearborn, MI.
对于患有强迫性障碍 (OCD) 的成年人,部分对血清素再吸收抑制剂 (SRIs) 的反应,拉莫特里金 (lamotrigine),孟坦丁 (memantine) 和阿里皮普拉 (aripiprazole) 显示出最有前途的增强剂. 如果aripiprazole不能耐受,risperidone是一种潜在的替代品.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 强迫症 (OCD) 影响全球2-3%的成年人.
- 虽然血清素再吸收抑制剂 (SRIs) 是有效的,但40-60%的患者只有部分症状改善.
- 本综述评估了SRI非响应者的增强剂.
结论:
- 建议使用拉莫特里金,孟坦丁和阿里皮普拉来增强部分强迫症反应患者的SRI治疗.
- 如果aripiprazole不能耐受,risperidone是一种可行的替代抗精神病药物.
- 增强策略表现出不同的疗效,需要个性化治疗方法.
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