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放射治疗期间头癌的营养影响症状:一项纵向研究
Minmin Li1, Chris Nutting2,3, Tao Zhang1
1Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Acta oto-laryngologica
|June 19, 2023
概括
接受放射治疗的头癌患者经常经历营养影响症状 (NIS),如口味变化和口腔干燥,导致显著的体重减轻. 早期营养干预对于改善结果至关重要.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 辐射疗法 辐射疗法
背景情况:
- 接受放射治疗 (RT) 的头癌 (HNC) 患者容易显著减肥 (WL).
- 营养影响症状 (NIS) 是该患者群体中WL的主要贡献者.
- 了解RT期间NIS的进展对于管理WL至关重要.
研究的目的:
- 为了前性地研究HNC患者在RT期间NIS的变化.
- 分析这些NIS对体重和治疗结果的影响.
- 为了确定显著影响WL和临床结果的特定NIS.
主要方法:
- 一项前性观察性研究,涉及94名接受RT的HNC患者.
- 使用头部和部患者症状检查清单对NIS的评估.
- 在RT期间和治疗后12个月的多个时间点评估体重,血红蛋白和淋巴细胞.
- 使用通用估计方程 (GEE) 和肯德尔的tau-b进行统计分析.
主要成果:
- 疼痛,味道变化和口腔干燥是最常见的NIS (>90%),干扰得分高.
- 平均WL为4.22±3.59公斤;67%的人经历了>5%的WL.
- 缺乏能量,吐和口味变化显著影响了WL (p < .05).
- 味觉变化与降低的血红蛋白和淋巴细胞相关 (p = .018,p < .001).
- WL与瘤反应负相关 (p = .031).
结论:
- 在接受RT的HNC患者中常见的NIS包括味道变化,疼痛,口腔干燥和吐.
- 早期的营养干预,最好是在RT的前10天内,可以积极改变营养状况.
- 通过早期干预改善营养状况,可能会为HNC患者带来更好的临床结果.
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