患者骨折:一项基于全国人口的队列研究
Marija Babunovska1, Aleksandar Jovanovski2, Bojan Boskovski1
1University Clinic for Neurology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, North Macedonia.
Epilepsia open
|June 19, 2023
概括
患有的人 (PWE) 的骨折患病率明显高于普通人群,特别是头骨和骨折. 骨折风险增加与使用两种以上的抗发作药物 (ASM) 和并发症有关.
科学领域:
- 流行病学 流行病学
- 整形外科 整形外科 整形外科
- 神经学 神经学
背景情况:
- 骨折是一个重大的健康问题,特别是在弱势群体中.
- 了解患者骨折患病率 (PWE) 对有针对性的干预至关重要.
研究的目的:
- 确定与普通人群相比,患者骨折的年龄,性别和特定部位的患病率.
- 确定与PWE骨折相关的风险因素,包括抗发作药物 (ASM) 使用和并发症.
主要方法:
- 在北马其顿 (2015-2018) 开展了一项基于全国人口的研究,利用电子健康记录.
- 系统地选择PWE和匹配的一般人群对照.
- 计算周期流行率,发病率比率 (IRR),几率比率 (OR) 和骨折风险比率 (RR).
主要成果:
- 与对照组 (8/1000) 相比,PWE的骨折患病率 (109/1000) 显著更高.
- 在PWE中,头骨和下骨折的发生率大约是PWE的100倍.
- 骨折风险增加与使用两种以上的ASM (OR:1.56) 和并发症的存在 (OR:1.24) 相关.
结论:
- 这项研究强调,与普通人群相比,PWE中骨折的患病率显著更高.
- 针对PWE小组,特别是多种ASM或并发症的小组,建议采取有针对性的骨折预防策略.
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