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在治疗类风湿性关节炎的表观遗传,细胞和分子途径的当前趋势

Rashita Makkar¹, Aayush Sehgal², Sukhbir Singh³

¹Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.

Inflammopharmacology

|June 19, 2023

概括

类风湿性关节炎是一种自身免疫性关节疾病,影响1%的人口. 本综述涵盖了它的发病,细胞机制和当前治疗方法,以获得更好的治疗策略.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
病理学病理学病理学

背景情况:

风湿性关节炎 (RA) 是一种慢性,全身性自身免疫性疾病,主要影响关节,其特征是关节组织的炎症和破坏.
关节炎影响全球近1%的人口,女性受影响的次数是男性的两倍,并且可以在任何年龄表现出来.
病理性特征包括免疫细胞透,突性增生,松形成和软骨/骨质侵蚀.

研究的目的:

为了审查类风湿性关节炎的发病原因.
探索导致RA的表观遗传,细胞和分子因素.
为 RA 管理的先进治疗方法的发展提供信息.

主要方法:

在类风湿性关节炎的病变发生的文献综述.
对RA细胞和分子机制的分析.
综合目前的RA治疗策略.

主要成果:

RA 患者的突纤维细胞表现出具有攻击性的表型,可以调高原基因,粘附分子,炎症性细胞因子和矩阵降解酶的调节.
细胞因子和化学因子有助于RA症状,如胀和疼痛,通过促进结膜炎症和松形成.
目前的治疗方法包括NSAIDs,DMARDs和生物药物 (例如TNF-α和白内素抑制剂),提供症状缓解和疾病管理.

结论:

了解RA病变发生,包括表观遗传和分子因素,对于开发改进的治疗方法至关重要.
针对特定的细胞和分子通路提供了更有效的RA管理的潜力.
这一综述为推进针对类风湿性关节炎的治疗策略提供了基础.

关键词:

自身免疫性疾病是一种自身免疫性疾病.细胞细胞的细胞.在表观遗传学上,表观遗传学是表观遗传学.免疫反应的免疫反应.炎症性细胞因子是炎症性细胞因子.类风湿性关节炎类风湿性关节炎类风湿性关节炎

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