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波拉在老鼠模型中对逆流性食道炎的治疗效果
Wenbo Xie1, Lu An1, Zhaoyang Liu2
1National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130000, China.
Digestive diseases and sciences
|June 19, 2023
概括
波拉 (PZ) 和埃索梅普拉 (PPI) 通过减少炎症标志物,有效地治疗老鼠的逆流食道炎 (RE). 结合PZ和PPI为RE提供了卓越的治疗效果.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 逆流性食道炎 (RE) 是一种以食道炎症为特征的疾病.
- 了解埃索梅普拉 (PPI) 和波拉 (PZ) 等药物的治疗机制对于RE管理至关重要.
研究的目的:
- 研究PPI,PZ及其组合在RE的老鼠模型上的保护和治疗作用.
- 阐明涉及炎症标志物和信号通路的潜在治疗机制.
主要方法:
- 威斯塔尔大鼠被诱导用RE,并用PPI,PZ或两者一起治疗.
- 胃心脏组织通过ELISA分析了中白素-8 (IL-8) 和前列腺素E2 (PGE2) 的水平.
- PI3K/Akt/mTOR通路 (EGFR,Akt,p-Akt,p-mTOR) 的蛋白质表达被评估使用西欧涂抹.
主要成果:
- 两种PPI和PZ治疗都显著降低了RE大鼠的IL-8和PGE2水平的升高.
- PZ对降低IL-8产生了强烈的影响,而PPI+PZ在酸性戒断组中对PGE2降低最有效.
- 在酸性持久性组中,PPI在降低IL-8和PGE2方面最有效,而PZ也显示出显著的改善.
- 治疗降低了RE模型中观察到的PI3K/Akt/mTOR通路蛋白的增加表达.
结论:
- 波拉在RE中显示出显著的治疗效果,减少炎症和降低PI3K/Akt/mTOR通路的调节.
- 波拉对RE的治疗效果与埃索梅普拉的治疗效果相当.
- 与PPI和PZ结合治疗在治疗反流性食道炎方面提高了疗效.
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