早期发病和常见痛风之间的比较:一个系统的文献评论
Anthony J Amatucci1, Lissa Padnick-Silver2, Brian LaMoreaux1
1Horizon Therapeutics plc, 1 Horizon Way, Deerfield, IL, 60015, USA.
Rheumatology and therapy
|June 19, 2023
概括
早期发病的痛风 (EOG) 患者经历了更严重的疾病,对治疗的反应较小. 建议对这些年轻患者进行早期风湿学转诊和向性尿酸降低疗法.
科学领域:
- 类风湿病学 类风湿病学
- 代谢疾病 代谢疾病
- 遗传学 遗传学是一种遗传学.
背景情况:
- 痛风是一种普遍的炎症代谢疾病,具有显著的并发症.
- 早期发病的痛风 (EOG),在40岁或之前被诊断出,影响约60万美国人.
- 关于EOG的临床特征,并发症和治疗结果的数据有限.
研究的目的:
- 系统地审查有关早期发病痛风 (EOG) 的现有文献.
- 了解EOG的临床特征,并发病概况和治疗反应.
- 为了比较EOG与常发性痛风 (CG).
主要方法:
- 在PubMed和ACR/EULAR抽象档案中进行系统的文献搜索.
- 纳入标准侧重于早期发病的痛风和相关的比较.
- 排除无关,外语,单一案例或较旧的出版物 (2016年以前) 的排除.
主要成果:
- 包括 17 篇出版物 (12 篇文章,5 篇摘要) 来自 283 个已识别.
- 与CG患者相比,EOG患者在诊断时表现出较少的心脏代谢和并发症.
- EOG患者出现了更严重的疾病,更高的血清尿酸水平,以及对口服尿酸降低疗法的反应较差,尿酸载体突变的发病率更高.
结论:
- EOG通常对尿酸降低疗法不乐观,并且与尿酸输送器缺陷有关.
- 建议对EOG进行早期风湿病学转诊和治疗到目标的尿酸降低策略.
- 通过早期血清尿酸控制,EOG提供了一个潜在的窗口来预防并发病.
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