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甲状腺激素和胆结石疾病之间的关系的性别依赖的差异在euthyroid受试者中
Guoli Liu1, Xiao Zheng2, Yuzhen Jia1
1Department of Geriatrics and Respiratory Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, Shandong Province, P. R. China.
Medicine
|June 19, 2023
概括
甲状腺功能与胆结石病 (GSD) 的相关性在无甲状腺患者中进行了研究. 低的TT3/TT4比率和高的TT4水平与男性的GSD有关,但与女性无关.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 甲状腺功能障碍与胆结石病 (GSD) 有关.
- 有限的数据存在于甲状腺功能和GSD在euthyroid个体.
- 这项研究研究了甲状腺功能和GSD在一个大 euthyroid队列.
研究的目的:
- 为了检查甲状腺功能测试 (TSH,TT3,TT4,TT3/TT4比率) 和GSD存在之间的关联.
- 为了确定这些协会是否因性别而有所不同.
- 为了提供有关GSD风险因素的洞察力,euthyroid种群.
主要方法:
- 包括4958名来自健康检查的甲状腺功能良好的受试者.
- 通过使用肝脏超声波来诊断GSD.
- 评估甲状腺功能 (TSH,TT3,TT4,TT3/TT4) 和传统的GSD危险因素.
主要成果:
- 总的来说,甲状腺功能参数和GSD之间没有发现显著的关联.
- 在男性中,较低的ln(TT3/TT4) 比率 (OR:0.551) 和较高的TT4 (OR:1.077) 与GSD有关.
- 没有甲状腺功能参数与女性的GSD有显著的关联.
结论:
- 甲状腺功能参数在整体甲状腺功能队列中与GSD没有显著的关联.
- 低的TT3/TT4比率和高的TT4水平独立地与高甲状腺男性的GSD有关.
- 这些关联并没有在甲状腺功能良好的女性中观察到,这表明性别特异性关系.
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