关于前列腺癌风险的ESR2多态:系统性审查和元分析
Xueliang Chang1, Hu Wang, Zhan Yang
1Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Medicine
|June 19, 2023
概括
ESR2 rs1256049基因多态性与前列腺癌 (PCa) 风险有关,在白人中增加,但在亚洲人中降低. rs4986938的多态性与PCa敏感性没有关联.
科学领域:
- 遗传学和基因组学 在
- 癌症研究 癌症研究
- 分子生物学分子生物学
背景情况:
- 雌激素受体2 (ESR2) 基因在各种细胞过程中发挥作用.
- 基因变异,特别是ESR2中的多态性,正在研究它们与癌症易感性的潜在联系.
- 这次分析的重点是两个关键的ESR2基因多态,rs1256049和rs4986938.
研究的目的:
- 评估两个ESR2基因多态 (rs1256049和rs4986938) 与患癌症的风险之间的关联.
- 具体来说,要确定这些多形态是否会影响前列腺癌 (PCa) 的易感性.
主要方法:
- 进行了全面的元分析,包括符合条件的候选基因研究.
- 在PubMed,Medline和Web of Science数据库中进行文献搜索,截至2022年5月10日.
- 统计分析,包括试验顺序分析,子组和灵敏度分析,用于评估异质性和确认发现.
主要成果:
- 该元分析包括10项研究,其中包括18 064例病例和19 556例对照,用于两个ESR2多态.
- ESR2 rs1256049多态性与高加索人的PCa风险增加和亚洲人的风险降低有关.
- 在ESR2 rs4986938多态和PCa风险之间没有发现显著的关联.
结论:
- 在高加索人群中,ESR2 rs1256049多态是前列腺癌的潜在危险因素.
- 相反,ESR2 rs1256049多态性似乎在亚洲人群中对前列腺癌产生保护作用.
- ESR2 rs4986938多态性与前列腺癌风险没有明显关联.
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