在健康人群中,肠道微生物群的益生菌调节由Bacillus coagulans MTCC 5856:一个随机,双盲,安慰剂控制的随机研究
Muhammed Majeed1,2, Kalyanam Nagabhushanam2, Lakshmi Mundkur1
1Sami-Sabinsa Group Limited, Bangalore, Karnataka, India.
Medicine
|June 19, 2023
概括
补充Bacillus coagulans (LactoSpore®) 对健康的成年人来说是安全的,并且对肠道微生物群的影响最小. 它可以促进有益的细菌,支持肠道健康,没有不良事件.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 益生菌被认为可以在不良的个体中重新平衡肠道微生物群.
- 益生菌对健康个体肠道微生物群的影响仍未得到充分研究.
- 凝血杆菌 (Weizmannia coagulans) 微生物类型培养系列5856 (LactoSpore®) 是一种益生菌补充剂.
研究的目的:
- 评估LactoSpore®补充剂对健康印度成年人肠道微生物群组成的影响.
- 为了评估健康的印度成年人LactoSpore®补充剂的安全性.
主要方法:
- 一个为期28天的随机对照试验,涉及30名健康的印度成年人.
- 参与者每天接受LactoSpore® (2亿CFU/囊) 或安慰剂.
- 用16S rRNA amplicon测序和定量PCR进行细菌计数,分析了便样本.
主要成果:
- 没有报告任何不良事件或一般健康状况或血液生物化学参数的显著变化.
- 对肠道微生物组的metataxonomic分析表明,肠道微生物组的变化最小,保持了Bacteroidetes和Firmicutes的平衡.
- 在益生菌组中观察到有益细菌的相对丰富度显著增加,包括Prevotella,Faecalibacterium,Blautia,Megasphaera和Ruminococcus.
结论:
- 拉克托斯波®是安全的消费,并没有显著改变健康个体的肠道微生物群.
- 特定细菌物种的微小变化甚至在健康的肠道中也可能带来好处.
- 证实了B. coagulans微生物类型培养集合5856的安全性,支持其作为食补充剂的使用,并需要在异位生物种群中进一步研究.
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