在怀孕和哺乳期早期使用rhPTH(1-84) 治疗低副甲状腺症
E Pauline Liao1, Natalie E Cusano1
1Department of Medicine, Division of Endocrinology, Lenox Hill Hospital, New York, New York, USA.
Endocrinology, diabetes & metabolism case reports
|June 19, 2023
概括
本案例研究探讨了怀孕和哺乳期间在低甲状腺患者中复合人性副甲状腺激素 (1-84) 的使用情况. 结果表明潜在的安全性,但需要更多关于怀孕期间rhPTH{1-84}的研究.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 怀孕和哺乳期间的甲状腺功能低下症管理由于矿物质代谢的改变而带来挑战.
- 重组人副甲状腺激素 (1-84) [rhPTH(1-84) ]已被批准用于低副甲状腺症,但缺乏怀孕和哺乳期的安全数据.
- 常规疗法可能对一些甲状腺下腺体患者来说不足.
研究的目的:
- 报告在怀孕和哺乳期早期的甲状腺功能低下患者中首次使用rhPTH(1-84).
- 评估临床过程和对母亲和她的后代的结果.
主要方法:
- 一个单一的病例报告,一个患有术后副甲状腺功能障碍症的患者.
- 在美国批准后开始使用rhPTH ((1-84) 治疗,并在产后和哺乳期继续治疗.
- 监测母亲和婴儿血清水平以及婴儿发育里程碑.
主要成果:
- 在母乳养期间,患者在产后恢复了rhPTH{1-84};8周后婴儿水平处于正常范围内.
- 据报道,这位患者生下的两个孩子都很健康,并达到发展里程碑.
- rhPTH(1-84) 在随后的怀孕期间因产品召回而停止使用.
结论:
- 这一案例表明,rhPTH ((1-84) 可能是怀孕和哺乳期低甲状腺患者的可行选择.
- 进一步的综合性研究是必要的,以确定rhPTH的安全性概况在孕妇和哺乳期的个体.
- 这些发现强调了需要继续研究在生殖期间管理复杂的内分泌条件的必要性.
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