在手术前和治疗后的质瘤患者中,揭示瘤微观结构与振荡扩散编码MRI
Ante Zhu1, Robert Shih2,3, Raymond Y Huang4
1GE Research, Niskayuna, New York, USA.
Magnetic resonance in medicine
|June 19, 2023
概括
振荡梯度旋回回声 (OGSE) 扩散MRI揭示了质瘤患者的组织微观结构. 时间依赖的扩散性测量标志着瘤异质性和细胞密度,有助于诊断和治疗评估.
科学领域:
- 神经成像是一种神经成像.
- 生物物理学的生物物理.
- 在瘤学瘤学.
背景情况:
- 质瘤表现出复杂的微观结构变异.
- 组织微观结构的准确表征对于质瘤的诊断和管理至关重要.
- 目前的扩散MRI技术可能无法完全捕捉质瘤微环境的异质性.
研究的目的:
- 研究由振荡梯度旋回回声 (OGSE) 扩散MRI测量的时间依赖扩散的实用性,用于表征质瘤患者内的组织微观结构.
- 为了将OGSE衍生的扩散度指标与细胞密度和瘤特征相关联.
主要方法:
- 使用超高性能梯度3.0TMRI获取OGSE扩散MRI数据 (30-100Hz) 和常规脉冲梯度旋转回声 (0Hz) 在五名成年质瘤患者中.
- 计算的明显扩散系数 (ADC) 和跟踪扩散加权成像 (TraceDWI) 在各种频率上.
- 分析了手术前和治疗后质瘤病变的扩散时间依赖性.
主要成果:
- 高度质母细胞瘤显示较高的ADC和较低的TraceDWI与低度星细胞瘤相比,在相当的OGSE频率下.
- 治疗后增强的病变表明瘤进展,比那些归因于治疗效果的病变具有更高的ADC和更低的TraceDWI.
- 不增强的病变和透性瘤区域显示出高的扩散时间依赖性,与增加的细胞密度一致.
结论:
- 基于OGSE的时间依赖的扩散性有效地区分了质瘤患者的组织微观结构.
- 这些扩散性特征与细胞密度相关,可以区分瘤类型,进展和治疗效果.
- OGSE扩散MRI为评估质瘤异质性的非侵入性评估提供了一个有希望的方法.
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