亚治疗性氧化氨酸度与狼的疾病活性增加和更大的器官损伤有关
Ji-Hyoun Kang1, Sung-Eun Choi1, Dong-Jin Park1
1Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea.
Rheumatology (Oxford, England)
|June 19, 2023
概括
系统性红斑狼 (SLE) 患者的亚治疗血清氧化 (HCQ) 水平与疾病活性增加和器官损伤相关. 维持适当的HCQ度对于有效管理SLE至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 临床药理学 临床药理学
背景情况:
- 氧化 (HCQ) 是系统性红斑狼 (SLE) 的基石治疗方法之一.
- 血清HCQ度监测有可能优化治疗疗效.
- 了解HCQ水平与SLE的长期结果之间的关系至关重要.
研究的目的:
- 评估血清HCQ度对临床表现,疾病活性和器官损伤在纵向SLE队列中的影响.
- 为了确定亚治疗性HCQ水平是否与随着时间的推移更差的临床结果有关.
主要方法:
- 这是一项为期5年的纵向研究,对338名SLE患者进行了研究.
- 患者在基线被分为次治疗 (<500 ng/ml) 和治疗 (≥500 ng/ml) 血清HCQ组.
- 综合估计方程 (GEE) 分析用于评估HCQ水平与临床结果之间的关联,包括医生的全球评估 (PGA),调整后平均SLEDAI-2000 (AMS) 和SLICC损伤指数 (SDI).
主要成果:
- 大多数患者 (84.9%) 在基线时具有亚治疗性HCQ水平.
- 亚治疗组表现出较高的新发性狼性炎 (LN) 的发病率.
- 在5年的研究期间,亚治疗性HCQ水平与更高的AMS,PGA和SDI得分显著相关.
结论:
- 亚治疗性血清HCQ度与新发性狼性炎的发展有关.
- 维持治疗性HCQ水平与更好的疾病控制和SLE患者减少累积器官损伤有关.
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