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相关概念视频

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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相关实验视频

Updated: Jul 26, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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SIRT3 激活剂 红 抑制 Th17 细胞分化并缓解结肠炎

Xiaotian Chen1,2, Mingming Zhang3, Fan Zhou4

  • 1Department of Clinical Nutrition, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, P.R. China.

Inflammatory bowel diseases
|June 19, 2023
PubMed
概括

红 (HKL) 提取物从马格诺利亚树皮减少T辅助17细胞分化,通过激活SIRT3和抑制STAT3/RORγt通路,提供潜在的保护对结肠炎.

关键词:
辅助性T细胞17细胞在这里,我们是Honokiol.线粒体脱乙酶Sirt3是什么信号传导和转录的激活器 3 3性结肠炎是一种

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科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 辅助性T细胞17 (Th17) 参与了诸如性结肠炎 (UC) 等炎性肠道疾病的发病.
  • 红醇 (HKL) 是一种天然的马格诺利亚树皮提取物,可激活Sirtuin-3 (SIRT3),并被认为具有抗炎性质.

研究的目的:

  • 在结肠炎的背景下,研究霍诺基 (HKL) 对Th17细胞分化的抑制作用.
  • 探索涉及SIRT3和STAT3/RORγt信号通路的潜在分子机制.

主要方法:

  • 在UC患者和健康对照中分析血清细胞因子,T细胞子集,SIRT3和p-STAT3/RORγt.
  • 在实验室中对T细胞的分化和从小鼠和人类样本中获得的Th17细胞的两极分化,用HKL治疗.
  • 在体内研究使用硫酸 (DSS) 诱导的大肠炎和IL-10缺乏的小鼠治疗HKL.

主要成果:

  • 与对照组相比,UC患者的IL-17和Th17比例较高,IL-10和SIRT3水平较低.
  • 在实验室中,HKL降低了IL-17和Th17细胞比率,独立于STAT3激活.
  • 在体内,HKL治疗改善了结肠炎参数,减少了Th17细胞种群,增加了SIRT3表达,并抑制了STAT3酸化和RORγt表达.

结论:

  • 红醇 (HKL) 通过通过SIRT3激活调节Th17细胞分化,显示出对大肠炎的保护作用.
  • 抑制STAT3/RORγt信号通路是HKL发挥抗炎作用的关键机制.
  • 在炎症性肠病研究中,HKL是潜在的治疗候选者.