评估住院后因检查点抑制剂的免疫相关不良事件而导致的生存率
Jordyn Silverstein1, Francis Wright1, Michelle Wang2,3
1Department of Internal Medicine, University of California, San Francisco, San Francisco, CA, USA.
The oncologist
|June 19, 2023
概括
由于免疫检查点抑制剂 (CPI) 的严重免疫相关不良事件 (irAEs) 的住院病例正在增加. 生存结果根据irAE和癌症的类型有很大差异,肺部irAE和肺癌与较差的生存率有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 免疫检查点抑制剂 (CPI) 越来越多地用于癌症治疗.
- 这导致由于严重的免疫相关不良事件 (irAEs) 的住院病例增加.
研究的目的:
- 为了识别因irAEs而住院的患者.
- 描述基于irAE类型,CPI疗法和癌症类型的生存结果.
主要方法:
- 从2012年1月到2020年12月,对因irrAEs住院的患者进行了回顾性分析.
- 使用卡普兰-梅尔曲线和日志等级测试进行生存分析.
主要成果:
- 在3137名患者中,有114名患者 (3.6%) 由于irrAEs而住院.
- 胃肠道/肝脏,内分泌和肺部irrAEs是最常见的.
- 住院后的中位生存期为980天.
- 肺部irrAEs和肺癌与明显更差的生存率有关.
- 组合CPI治疗显示了比PD-L) 1抑制剂更长的中位生存期.
结论:
- 预计随着CPI的使用,与irAE相关的住院病例将增加.
- 住院IRAE患者的生存结果因IRAE和癌症类型而异.
- 调查结果可以为患者的咨询和治疗决定为严重的IRE提供信息.
相关概念视频
Cell-mediated Immune Responses
69.1K
Overview
69.1K
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Kidney Transplant III: Nursing Management
41
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
41
Myocarditis IV: Nursing Management
13
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
13


