环境污染物前和多醇基物质与成年人心电图参数障碍有关
Yuan-Yuan Fan1, Chu Chu2, Yun-Ting Zhang1
1Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Journal of hazardous materials
|June 19, 2023
概括
暴露于per-和多醇基物质 (PFAS) 与心脏电活动的改变有关. 这项研究发现,PFAS与成人心率,QRS持续时间和PR间隔的变化有关.
科学领域:
- 环境健康 环境健康
- 心脏病学 心脏病学
- 毒理学 毒理学 毒理学
背景情况:
- 环境污染物可能会影响心脏功能.
- 有限的证据表明,和多基基物质 (PFAS) 与心脏导电系统的影响是有限的.
研究的目的:
- 调查血清PFAS暴露与成年人心电图 (ECG) 参数之间的关联.
- 探索PFAS对心脏导电的单独和联合影响.
主要方法:
- 招募了来自中国广州的1229名成年参与者.
- 分析了13种PFAS的血清水平.
- 使用通用线性模型 (GLMs) 和贝叶斯内核机器回归 (BKMR) 来评估与6个心电图参数 (HR,PR,QRS,QTc,QRS轴,电压) 的关联.
主要成果:
- PFAS暴露与心率 (HR) 降低和QRS持续时间显著相关.
- 随着PFAS暴露,观察到PR间隔的延长.
- 使用BKMR发现了PFAS与HR,PR间隔和QRS持续时间的显著联合关联.
结论:
- 血清PFAS暴露与心脏电活动的改变有关,特别是影响心率和导电间隔.
- 这些发现强调了与PFAS暴露相关的潜在心血管风险.
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