与孕前相关的胎盘病理的模式
Alexa A Freedman1, Sunitha Suresh1, Linda M Ernst2
1Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL, United States.
Placenta
|June 19, 2023
概括
孕产妇血管阻 perfusion (MVM) 是一个关键的胎盘损伤在早期预先怀孕,随着怀孕的减少. 隐性类分析揭示了明显的胎盘病理亚型,MVM与早产有很强的联系.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 病理学 病理学 病理学
背景情况:
- 孕前是一种常见的妊娠并发症.
- 孕产妇血管阻 perfusion (MVM) 经常在早期发病的孕前中观察到.
- 在孕前症中胎盘病理的患病率和模式需要进一步调查.
研究的目的:
- 为了调查胎盘病理的模式在孕前.
- 根据分娩时间来比较胎盘病理.
- 通过对胎盘变量进行潜在类别分析,识别出明显的孕前的亚型.
主要方法:
- 对被诊断患有妊娠前 (2009-2018) 的单子活产儿电子健康记录的回顾性分析.
- 在病理学报告中进行文本搜索,以确定MVM,FVM,CI和AI的病变.
- 对22个胎盘变量进行潜在类分析 (LCA),以确定子前的亚型.
主要成果:
- 随着妊娠年龄的提高,MVM的患病率显著下降 (95.4%在<34周到50%在≥37周).
- LCA确定了五种不同类型的胎盘病理:高度MVM,CI和FVM,低度MVM,AI和其他.
- 在不同班级中,早产率差异很大,在MVM特征的班级中,出生率最高 (87.6%在高档MVM),在AI班中最低 (23.5%).
结论:
- 孕前的胎盘病理异质,并且根据分娩时的妊娠年龄不同.
- MVM是早期发病的孕前的主要发现,与早产严重相关.
- 鉴定到的亚型表明多种潜在的病理生理机制有助于先兆子.
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