咳和咳过敏是喘可治疗的特征
Kefang Lai1, Imran Satia2, Woo-Jung Song3
1The First Affiliated Hospital of Guangzhou Medical University, National Center of Respiratory Medicine, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
The Lancet. Respiratory medicine
|June 19, 2023
概括
喘中的咳是复杂的,与控制较差和其他条件有关. 了解它的机制是开发针对性治疗以更好地管理喘的关键.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床免疫学临床免疫学
背景情况:
- 咳是喘患者普遍和破坏性的症状,通常表明喘控制减少和恶化增加.
- 在喘中导致咳的潜在潜在原因或并发症包括鼻炎和支气管炎.
- 乙酸性炎症和支气管收缩是关键机制,涉及喘中的急性和慢性咳.
研究的目的:
- 探索喘中咳的多面性质.
- 调查咳过敏和增强的阴道感官神经刺激性在喘相关咳中的作用.
- 审查当前和潜在的治疗策略,以控制喘中的咳.
主要方法:
- 文献综述和现有关于喘咳的研究的综合.
- 分析喘病理生理学,并发症和咳机制之间的相互作用.
- 基于潜在的咳病因学的治疗反应的评估.
主要成果:
- 咳过敏症,以喉麻醉,全和高为特征,可能通过增强上呼吸道神经感官活动促进喘咳.
- 与支气管收缩和2型炎症相关的喘咳通常对吸入性皮质类固醇和长效β-激动剂治疗有反应.
- 在成年人中,语音和语言治疗和像 gabapentin 这样的神经调节剂是咳过敏的潜在治疗方法;然而,在儿童中,喘,咳敏感性和严重性之间缺乏一致的关联.
结论:
- 喘中的咳是多因素的,包括炎症,支气管收缩和潜在的咳过敏.
- 向疗法,包括吸入性皮质类固醇,长效β-激动剂,语音疗法和神经调节剂,对喘中的特定咳表型有希望.
- 进一步的研究是必不可少的,以建立咳作为可靠的喘控制措施,阐明潜在的机制,并开发个性化治疗咳在所有年龄段的喘.
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