在眼睛高血压治疗研究的药物分支中的风险计算
Ari Leshno1, Carlos Gustavo De Moraes2, George A Cioffi2
1Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ophthalmology. Glaucoma
|June 19, 2023
概括
眼睛高血压治疗研究 (OHTS) 计算器准确预测治疗眼睛高血压患者的玻璃眼风险. 在治疗开始后重新计算风险为疾病管理提供了宝贵的见解.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 临床试验分析
背景情况:
- 风险评估对于管理眼睛高血压 (OHTN) 至关重要.
- 眼睛高血压治疗研究 (OHTS) 计算器是预测青光眼症进展的工具.
研究的目的:
- 评估正在接受治疗的OHTN患者中OHTS 5年风险计算器的预测准确度.
- 为了评估计算器对OHTS药物治疗手臂的概括性.
主要方法:
- 一个随机临床试验的后期分析,涉及OHTS药物手臂的726名参与者.
- 将药物组的危险比率 (HR) 与OHTS计算器的HR比较,使用z-test.
- 在24个月内使用未经治疗的基线眼内压力 (IOP) 和平均治疗的眼内压力 (IOP) 评估计算器性能.
主要成果:
- 药物臂的OHTS计算器HRs与未经治疗的OHTN使用的HRs没有显著差异 (P>0.1).
- 该计算器表现出治疗IOP的良好预测准确性 (校准基平方=10) 和未经治疗的基线IOP (基平方=29) 的较差准确性.
- 在接受治疗的IOP (c-统计 = 0.77) 时,差别很好,类似于OHTS观察组的先前发现.
结论:
- 该OHTS计算器适用于治疗OHTN的患者.
- 在开始IOP降低治疗后定期重新计算风险可以增强疾病管理策略.
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